By Franz Joel Leong, Veronique Dartois, Thomas Dick
An annual dying toll of two million, coupled with emerging drug resistance, highlights the necessity for the advance of latest medicinal drugs, larger diagnostics, and a tuberculosis (TB) vaccine. Addressing those key concerns, a colour Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, scholars, scientists, and medical professionals operating, studying, and instructing within the box of TB. It comprises a hundred colour photos and illustrations that deliver readability to the data offered. The atlas takes the bizarre procedure of protecting a number of species histopathology, arguably the 1st and fairly almost certainly the one source to take action. It presents an easy, annotated, and visible presentation of the comparative histopathology of TB in human and animal types. The editors have compiled details that is helping TB scientists to tell apart among the gains of all significant animal versions to be had and to take advantage of them with their strengths and obstacles in brain. The ebook presents information for choosing the easiest animal model(s) to reply to particular questions and to check the efficacy of drug applicants.
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Additional info for A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect Immun, 76, 2333–2340. J. 2009. Eliminating latent tuberculosis. Trends Microbiol, 17, 183–188. II 29 Chapter 4 Anatomy and Histology of the Human Lung F. -M. -Y. , 1984; Kayser, 1992; Hasleton and Curry, 1996; Colby and Yousem, 1997), and this chapter 31 32 â•›â†œ◾â†œæ¸€ A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis serves as a review of the basic features necessary to understand the functional and pathological changes that can occur in this organ.
HIV coinfection, weakening the immune system, increases the chances of progression to active TB dramatically, resulting in catastrophic situations such as seen, for instance, in Africa (Donald and van Helden, 2009). The increase of drug-resistant TB clearly demands the discovery and development of new antimycobacterials. At the time of writing, a few new drug candidates—two novel nitroimidazoles and an ATP synthase inhibitor—entered clinical development. , 2008; Nathan, 2009). Developing new antimycobacterials to keep drug-resistant TB at bay is the primary objective for TB drug discovery.
It requires oxygen for growth and is rod shaped). Simple culture media are available to grow MTB in the lab. So is a whole range of experimental animal models, from mice to monkeys, to grow the bacillus in vivo. MTB is a facultative intracellular parasite. It can grow extracellularly as well as intracellularly, both in culture and inside human lesions. , 1998). Disease Manifestations and Treatment MTB is an obligate human parasite that attacks largely the lungs, although other organ systems can be affected such as the central nervous or the lymphatic system and bones and joints.