By Horace W. Davenport
This booklet examines the background of experimental learn in gastric secretion and digestion. the writer identifies the medical questions that experience occupied researchers and discusses the experiments that experience resulted in their options. through keeping apart facets of experimental research and tracing their evolution through the years, the e-book offers gastric physiologists and gastroenterologists with an excellent realizing of the highbrow heritage in their box.
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Extra resources for A History of Gastric Secretion and Digestion: Experimental Studies to 1975
I pooled the outer two, and I analyzed them for carbonic anhydrase. I counted the number of parietal cells in the middle section after I had fixed and stained it. As a control, I counted the parietal cells in successive sections, finding that the number in one section was not very different from the number in surrounding sections. When I plotted the carbonic anhydrase activity of the two slices against the number of parietal cells in the intermediate section, I found a suspiciously high correlation (Fig.
Gastric carbonic anhydrase. ) · I 1·0 0·8 0·6 ' I ' I I ' ,I • I 0·4 0·2 I 0 0 • • • ••• • •• 8 16 24 3? 40 48 56 Figure 1-17. Ordinates, carbonic anhydrase concentration in arbitrary units in slices of gastric mucosa of the cat in excess ofthat predicted from the number of oxyntic cells in adjacent slices. The broken line is the relation between enzyme concentration and oxyntic cell count from Figure 1-16. Abscissae, 1,000 surface epithelial cells in adjacent slices of oxyntic mucosa of the cat.
B: Ordinates, gastric juice iodide cci_ncentration in millimoles per Iiter. Abscissae, plasma iodide concentration in millimöles per Iiter. C: Ordinates, ratio of iodide concentration in plasma tothat in gastric juice. Abscissae, plasma iodide concentration in millimoles per Iiter. (From Davenport HW. The secretion of iodide by the gastric mucosa. //1 ;· v· . ------ ' 7 A 7t\ • • 32 / A HISTORY OF GASTRIC SECRETION AND DIGESTION tion of iodide in gastric juice is not independent of the rate of secretiono When Mason and Bloch plotted ratios found in 226 Observations against the volume-rate of secretion, they found that at the lowest rates the ratio was often above 20 and could be as high as 1700 At the highest rates, no ratio was over 21.