Adipose Tissue and Adipokines in Health and Disease by Giamila Fantuzzi

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By Giamila Fantuzzi

The box of adipose tissue biology has been increasing at a truly fast velocity within the previous few years. quite a few advances were made given that ebook of the 1st version of this e-book, by way of easy adipocyte biology, figuring out of the determinants of weight problems, distribution of physique fats and weight reduction, in addition to the mechanisms linking extra adiposity to numerous co-morbidities. Adipose Tissue and Adipokines in overall healthiness and disorder, moment Edition includes up to date chapters from the former quantity yet because the box has advanced, a few components lined within the first variation were refocused to handle the recent wisdom. the amount is split in 4 sections: the 1st take care of simple adipose tissue and adipokine biology, whereas the final deal with the matter of weight problems and changes in adipose tissue functionality from an epidemiological and medical perspective. The chapters are written by means of specialists of their fields and contain the freshest medical details. Adipose Tissue and Adipokines in healthiness and disorder, moment Edition is an invaluable source for physicians attracted to adipose tissue biology and uncomplicated scientists who need to know extra approximately utilized features of the sphere. The booklet ambitions endocrinologists, citizens and fellows, internists, nutritionists and basic practitioners who're uncovered to an ever-expanding overweight population.

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Finally, new lines of evidence analyzing how obesity impacts ASC abundance and functional potential are included. A. D. D. D. edu G. Fantuzzi and C. A. D. Tchoukalova Abbreviations ASCs WAT MSCs SVF ESCs iPSC hMADS APCs VAT SAT Pref-1 COL6A2 FRP2/SFRP2 DIPA Zfp423 LXRα BMP(s) IGF-1 FGF Lox Gpc4 Nr2f1 Shox2 En1 PBX1 Adipose stem cells or adipose-derived stem cells White adipose tissue Mesenchymal stem cells Stromovascular fraction Embryonic stem cells Induced pluripotent stem cells Human multipotent adipose-derived stem Adipocyte precursor cells Visceral adipose tissue Subcutaneous adipose tissue Preadipocyte factor 1 Type VI collagen alpha 2 chain Frizzled-related protein 2 Delta-interacting protein A Zinc-finger protein 423 Liver X receptor alpha Bone morphogenetic proteins Insulin-like growth factor-1 Fibroblast growth factors Lysyl oxidase Glypican 4 Nuclear receptor subfamily 2 group F member Short stature homeobox 2 Engrailed 1 Pre-B-cell leukemia transcription factor Introduction Adipocytes are highly specialized cells that form and store fat in adipose tissue and play a major role in energy homeostasis in vertebrate organisms.

Several laboratories have identified a source of multipotent stem cells, known as adipose-derived stem cells (ASCs) that are capable of proliferation and differentiation into multiple lineages in vitro and in vivo, including adipocytes, osteoblasts, chondrocytes, and myocytes [12–20]. ASCs have been defined by a variety of other terms, including the following: processed lipoaspirate cells, adipose-derived stromal cells, adipose-derived mesenchymal progenitor cells, and stromovascular fraction (SVF) (reviewed in [21]).

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