Airway Smooth Muscle in Asthma and COPD: Biology and by Kian Fan Chung

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By Kian Fan Chung

During this booklet, major researchers in medication and molecular pharmacology clarify the mobile mechanisms that keep an eye on airway gentle muscle. The capability through which those are disrupted in affliction, and the pharmacologic ideas in which they are converted are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity offers the clinician with the hottest info on one of many center physiological procedures in airway disorder, and gives insights into present and destiny ways to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates most recent study to bronchodilator therapyMulti-contributed textual content, co-coordinated via of the top specialists within the box.

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Et al. (1995). Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis. Am J Physiol 268, L894–L901. Kubo, R. (1986). Brownian motion and nonequilibrium statistical mechanics. Science 233, 330–334. Kuo, K. , Par´e, P. D. et al. (2001). Myosin thick filament lability induced by mechanical strain in airway smooth muscle. J Appl Physiol 90, 1811–1816. Kuo, K. , Herrera, A. , Wang, L. et al. (2003). Structure–function correlation in airway smooth muscle adapted to different lengths.

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Overby, D. , Alenghat, F. J. et al. (2004). Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochem Biophys Res Commun 313, 758–764. McParland, B. , Macklem, P. T. and Par´e, P. D. (2003). Airway wall remodeling: friend or foe? J Appl Physiol 95, 426–434. Mead, J. (1973). Respiration: pulmonary mechanics. Annu Rev Physiol 35, 169–192. -F. and Gunst, S. J. (1996). Role of contractile protein activation in the length-dependent modulation of tracheal smooth muscle force.

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