An atlas of depression by David S Baldwin; Jon Birtwistle

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By David S Baldwin; Jon Birtwistle

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Moclobemide in social phobia. A double-blind, placebo-controlled clinical study. Eur Arch Psychiatry Clin Neurosci 1997;247:71–80 22. The safety and tolerability of venlafaxine hydrochloride: analysis of the clinical trials database. J Clin Psychopharmacol 1996;16(suppl 2):54s–9s 7. Nutt D, Baldwin DS, Beaumont G, et al. Guidelines for the management of social phobia/social anxiety disorder. Prim Care Psychiatry 1999;5:147–55 8. Dingemanse J, Wood N, Guentert T, Oie S, Ouwerkerk M, Amrein R. Clinical pharmacology of moclobemide during chronic administration of high doses to healthy subjects.

TCAs should be avoided in younger patients, elderly patients, patients who drive, when drowsiness is unacceptable, when there is a risk of suicide attempts, when the therapeutic dose is not feasible, when there is preexisting cardiac disease or when long-term treatment is needed. TCAs are useful in cases where there has been a previous response to TCA treatment and when that previous treatment was well accepted. 5). 6): • 5-HT re-uptake inhibition and 5-HT receptor effects; • norepinephrine (NE) re-uptake inhibition; • anticholinergic effects; • antihistaminergic effects; and • adrenergi c effects.

Use during pregnancy should be avoided whenever possible, as teratogenic effects may be seen in up to 11% of births, cardiovascular malformations being among the more common abnormalities. 42 summarizes the side-effects of lithium. mended if response is partial. Lithium level should be assessed every 3 months, and an estimate of renal and thyroid function should be made every 6 months. Lithium should be discontinued slowly. Lithium levels can increase during concomitant treatment with diuretics, nonsteroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitors.

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